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    Description. Designed for professional use and in vitro diagnostic. Rapid chromatographic immunoassay test for the qualitative detection of IGFBP-1 (insulin-like growth factor binding protein 1), a major protein marker in amniotic fluid, in a vaginal swab.. RELIABLE: Sensitivity (true positive rate): 97.6%

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  • Pregnant Women Home Test Premature Rupture of

    2020-7-9 · This Test is one qualitative immunochromatographic test for the detection of IGFBP-1 in vaginal secretions. It is intended for use by health care professionals as an aid in the diagnosis of premature rupture of amniotic membranes (prom) in pregnant women where prom is suspected.

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    Actim PROM test is a visually interpreted, qualitative immunochromatographic dipstick test for detection of amniotic fluid in vaginal secretions during pregnancy. Actim PROM detects IGFBP-1, which is a major protein in amniotic fluid and a marker of the amniotic fluid in a vaginal sample.

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    The newest confirmatory test is the AmniSure®, which is a point of care immunochromatographic assay that detects trace amounts of placental alpha microglobulin-1 protein (PAMG-1) in vaginal fluid after rupture of fetal membranes. The analytical sensitivity of the test has been set at 5 ng/mL.

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  • Diagnostic Modalities in Premature Rupture of Membranes

    2015-2-24 · Diagnostic tests (nitrazine test, fern test, Insulin-like Growth Factor Binding Protein-1 “IGFBP-1” and Placental Alpha Microglobulin-1 “PAMG-1”) should be used when the diagnosis is not certain following history, examination with sterile speculum and ultrasonography evaluation.

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  • Diagnostic Accuracy of Insulin-like Growth

    2020-10-21 · The combined IGFBP-1/AFP (AmnioQuick Duo) test is an accurate bedside test with 97.6% sensitivity, 98.3% specificity, 98.4% PPV, 97.5% NPV, and 97.95% overall accuracy in the detection of PPRFM/PRFM. The sensitivity, specificity, PPV, NPV, and the overall accuracy of the AmnioQuick Duo were significantly higher than in the standard diagnostic ...

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    2017-6-30 · prématurés1. Le diagnostic est établi sur l’historique de la patiente et les signes cliniques. Cependant un diagnostic ... de l’IGFBp-1 par un test rapide, dans les sécrétions cervico-vaginales a démontré une ... fiable semble actuellement être l’IGFBP-1 PROm-Test par comparaison à d’autres

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  • IGFBP-1 Antibody (OTI6C7) [Alexa Fluor® 594] (NBP2 ...

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  • Actim PROM - superior accuracy | Actim

    The detection limit of Actim PROM excludes IGFBP-1 concentrations found in maternal blood, further increasing the specificity of the test for amniotic IGFBP-1. Actim PROM test reports PROM accurately, even for samples containing blood. The presence of blood does not affect the visual interpretation of the test at the 5-minute time-point.

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  • Evaluation of Insulin‐Like Growth Factor Binding

    2010-5-24 · Objective:To evaluate the diagnostic value of insulin-like growth factor binding protein-1 (IGFBP-1) as an indicator of ruptured fetal membranes. Methods:IGFBP- 1 concentrations were measured on 42 paired cervicovaginal samples before and after membrane rupture, using an immunoenzymatic assay.A PROM test [dipstick detecting IGFBP-1 with a cutoff value of 25 μg/l (A)], a BTB test …

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  • Evaluation of the performance of the insulin-like

    2021-1-14 · Behring Institut IGFBP-1 (PP12) preparation Lot 307/323). Analytical Sensitivity The analytical sensitivity (detection limit) of the Alere Actim PROM test was identified by evaluating different concentrations of IGFBP-1 in extracted samples on three different lots of the Alere Actim PROM test. Two different operators each interpreted

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  • Instructions for use

    • The only ROM diagnostic found to correlate 99% with indigo carmine intra-amniotic injection, recognized by ACOG as the ROM testing gold standard (7) • Demonstrated by multiple studies to be a more accurate aid in detecting PROM than other ROM tests, including IGFBP-1 (8, 9, 23, 26)

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    The newest confirmatory test is the AmniSure®, which is a point of care immunochromatographic assay that detects trace amounts of placental alpha microglobulin-1 protein (PAMG-1) in vaginal fluid after rupture of fetal membranes. The analytical sensitivity of the test has been set at 5 ng/mL.

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    2018-10-6 · 2 The test has been designed to minimize interference from bleeding, but in cases of heavy bleeding the blood locally may have a higher concentration of IGFBP-1 protein. In these cases, a positive result should be interpreted with caution. Actim PROM IFU. ©2018 CooperSurgical, Inc. 82670 Rev. 5/18

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  • AmniSure for Detection of Fetal Membrane Rupture

    2020-5-22 · the studies evaluated the AmniSure test in pregnant women who did not match the usual clinical criteria for assessing rupture of fetal membranes and another study evaluated an older form of the test.2,4-6 Cousins et al. (2005) performed the largest available study2 that evaluated the AmniSure test in women who had signs or symptoms of fetal membrane rupture.

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  • In Vitro Technologies :: News

    2016-12-7 · Tag: IGFBP-1 AmniSure: The effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests. Research shows that conventional diagnostic tests, such as nitrazine (pH), ferning, pooling and ultrasound can be inaccurate and invasive.

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  • AmniSure® PROM Test - Accurate PROM PPROM

    AmniSure ® is the only PROM diagnostic method with 99% correlation to the indigo carmine injection, the gold standard of PROM testing6. AmniSure ® is demonstrated in multiple studies to be a more accurate aid in detecting PROM than other tests, including IGFBP-1 biomarker tests 7-10. AmniSure ® is more accurate than the IGFBP-1 test in women ...

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  • ACTIM Prom Brochure - CooperSurgical

    2020-7-7 · IGFBP-1 µg/L 10 14 18 36–42 1 000 10000 1000 100 10 The IGFBP-1 level in amniotic fluid rises in early pregnancy and remains elevated throughout. For labs, Actim PROM controls can be frozen for up to one year9 for additional cost savings and convenience. Actim PROM is optimized to be so sensitive it detects even microruptures of membranes that

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  • [Analysis of cervicovaginal fluid in the diagnosis of ...

    In Poland various tests based on the analysis of vaginal pH and a test Actim Prom based on the analysis of IGFBP-1 are available. In clinical practice, approximately 10% of cases of PROM require additional confirmation, which can be difficult, especially in the outpatient setting.

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    2021-7-5 · 1. AmniSure ROM (Rupture of [fetal] Membranes) Test Instructions for Use. QIAGEN, 2019. 2. ROM plus Rupture of Membranes Test Instructions for Use. P/N 050-0642 REV E, 2016. 3. Actim PROM Instructions for Use OACE30831-9. Medix Biochemica, 2016. 4.

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  • UpToDate

    2019-6-3 · IGFBP-1 in the cervicovaginal fluid was measured by a rapid dipstick method (PROM test). AFI was measured by the four-quadrant method and an AFI of<80 mm was considered as oligohydroamnios. RESULTS The sensitivity, specificity and accuracy of the nitrazine test, the PROM test and AFI were 97, 16 and 56%, 97, 97 and 97% and 94, 91 and 92% ...

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  • DETECTION OF PREMATURE RUPTURE OF MEMBRANES

    2019-12-10 · The diagnostic tests presently used in clinically asymptomatic or suspicious cases include measurement of vaginal pH, alpha fetoprotein (AFP), human chorionic gonadotropin (hCG), diamine oxidase, prolactin, insulin growth factor binding protein-1 (IGFBP-1), fetal fibronectin and fern test. However, none of these tests

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  • ESTUDIO DE CONCORDANCIA ENTRE DOS PRUEBAS:

    2017-10-10 · con la prueba PAMG-1 (Amnisure) y 28,9 % con la IGFBP-1 (Actim-Prom); el único caso dispar resultó positivo a la amnionfusión con índigo de carmín. La concordancia entre ambas pruebas fue de 0,97. Conclusión: la IGFBP-1 demostró un desempeño similar a la PAMG-1 para el diagnóstico de ruptura de membranas.

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  • Preterm Birth and PROM Testing Market Size, Share,

    Introduction. The global market size of preterm birth and PROM testing was value at 1.11 billion at 2017 and is expected to reach 1.31 billion by the end of year 2026.The market is estimated to grow at a CAGR of 1.74% over the forecast period.. Market Dynamics. Premature rupture of membranes (PROM) is one of the main cause of preterm births.

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  • ROM Plus ES Rupture of Membranes Test - Clinical ...

    This product is not for sale in the U.S ROM Plus provides reliable sensitivity delivered conveniently and cost effectively. ROM Plus® is unique in that it detects both Alpha-fetoprotein (AFP) and Insulin-like growth factor-binding protein 1 (IGFBP-1) using a monoclonal/polyclonal antibody approach–improving its sensitivity. Timely and accurate diagnosis of PROM allows for

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  • Prelabour rupture of membranes: Overview of

    Over the review period the focus of diagnostic studies has been on two bedside test strips: insulin-like growth factor-binding protein-1 (IGFBP-1) and placental α microglobulin-1 (PAMG-1). Bedside tests improve the confidence of the clinician about their diagnosis. Compared to nitrazine or ferning test alone, IGFBP-1 and PAMG-1 are more accurate.

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    Designed for professional and in vitro diagnostic. For the detection of the rupture of fetal membranes (ROM) in pregnant woman from a vaginal swab sample. Simple and rapid immunochromatographic test that allows in vitro detection of two markers: IGFBP-1 & AFP. No speculum exam required. Advantages of AMNIOQuick ® DUO+

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  • Abbott Actim PROM Test, Pregnancy Test Strips,

    The Alere Actim PROM test is an accurate aid in the diagnosis of suspected Premature Rupture of Membranes. It is a rapid immunoassay that specifically detects Insulin-like Growth Factor Binding Protein -1 (IGFBP-1). IGFBP-1 accumulates at high concentrations in amniotic fluid.

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  • Headline the currently available methods.”

    2020-12-17 · IGFBP-1 83.9 87.8 Findings: Compared with its performance in women for whom membrane status is known, the performance of the IGFBP-1 test decreas-es significantly when used on patients for whom membrane status is unknown. In this latter clinically relevant population, the PAMG-1 test has higher accuracy than the IGFBP-1 test.

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  • Human IGFBP-1 ELISA Kit for serum, plasma, cell

    Human IGFBP-1 ELISA Kit for serum, plasma, cell culture supernatant and urine; find Sigma-Aldrich-RAB0232 MSDS, related peer-reviewed papers, technical …

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  • Diagnosis of premature rupture of membranes by

    diagnostic test for PROM in recent years” (18). These studies have mainly focused on biochemical agents with high concentration in amniotic fluid. Prolactin, alpha-fetoprotein (AFP), insulin like growth factor binding protein (IGFBP-1), fetal fibronectin (fFN), Lactat and beta-subunit of human

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  • Premature Rupture of Membranes and P-PROM -

    2017-6-30 · Alere™ Actim® PROM Détection fiable et rapide de la rupture prématurée des membranes fœtales Détection spécifique de l’IGFBP-1 (Insulin-like Growth Factor Binding Protein-1) du liquide amniotique dans les sécrétions vaginales (speculum non obligatoire) même en présence d’urine, de sperme et de sang1-4. Alere™ Actim® Partus

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  • 1ngeni pour les tests de diagnostic rapide PROM et Alere ...

    2021-7-15 · detecting PROM by evaluation of vaginal fluid urea and Creatinine concentration [2]. Other studies have measured beta human chorionic gonadotropin (β-HCG) level in the vaginal fluid for diagnosis of PROM [1, 5, 13, and 14]. In recent study sensitivity, specificity, positive and negative predictive values were 95.5, 94.7, 91.3 and 97.3%,

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