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    2021-7-25 · The PROM Rapid Test is a rapid qualitative immunochromatographic test for the detection of IGFBP-1 in vaginal secretions. The test is intended for use by health care professionals as an aid in the diagnosis of premature rupture of amniotic membranes (prom) in pregnant women where prom is suspected. Interpretation of Results

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    Description. Designed for professional use and in vitro diagnostic. Rapid chromatographic immunoassay test for the qualitative detection of IGFBP-1 (insulin-like growth factor binding protein 1), a major protein marker in amniotic fluid, in a vaginal swab.. RELIABLE: Sensitivity (true positive rate): 97.6%

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    2021-7-25 · The PROM Rapid Test is a rapid qualitative immunochromatographic test for the detection of IGFBP-1 in vaginal secretions. The test is intended for use by health care professionals as an aid in the diagnosis of premature rupture of amniotic membranes (prom) in pregnant women where prom is suspected. Interpretation of Results

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  • RESEARCH ARTICLE Open Access Meta-analysis of studies

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    Cite as: Abdelazim IA, Abu-Faza M. Fetal Fibronectin (Quick Check fFn Test) Versus Insulin-Like Growth Factor Binding Protein-1 (Actim PROM Test) for Detection of Premature Rupture of Fetal Membranes.

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    2021-4-21 · The mean level of IGFBP-1 in healthy adults is 4.4 μg/L (range 0.6-14.4 μg/L). After about 65 years of age, serum IGFBP-1 levels begin to increase. There is also an inverse correlation between body mass index (BMI) and fasting serum IGFBP-1 concentrations. The most important regulator of circulating IGFBP-1 is insulin.

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    2021-2-21 · with a recovery of only 70-80 % of IGFBP-bound IGF-I as a result of co-precipitation. The absolute results of such an extraction are therefore false low (15). The extraction removes IGF-I RIA, IGF-R20 100 Determinations Principle of the test Non - extractive radioimmunoassay Duration (incubation period) 2 days + 1.5 h

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  • In Vitro Technologies :: AmniSure: The effect of blood

    The IGFBP-1 test specificity decreased by 12.8 percentage points to a value of 75% whereas the PAMG-1 (AmniSure) test only decreased by 7 percentage points to a value of 91.5%. Showing that while the presence of vaginal bleeding impacts both tests the IGFBP-1 is much more affected than the PAMG-1 test.

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  • Diagnostic method for detecting the rupture of fetal ...

    1993-6-30 · A rapid diagnostic method for detecting the rupture of fetal membranes is disclosed. The presence of insulin-like growth factor binding protein 1 (IGFBP-1) in a vaginal secretion sample, resulting from the rupture of fetal membranes, is detected with the aid of at least one specific binding substance for IGFBP-1 .

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  • US5554504A - Diagnostic method for detecting the

    A rapid diagnostic method for detecting the rupture of fetal membranes is disclosed. The presence of insulin-like growth factor binding protein 1 (IGFBP-1) in a vaginal secretion sample, resulting from the rupture of fetal membranes, is detected with the aid of at least one specific binding substance for IGFBP-1 .

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    2012-9-12 · Fetal fibronectin was more accurate (91.8 %) for detection of PROM than Ferning (81.4 %) or Nitrazine (84.1 %) tests. The Quick Check fFN test® for detection of the fetal fibronectin in the vaginal fluid is a simple bedside test, more sensitive, and specific than Ferning and Nitrazine tests, it can be used as complimentary test to confirm the ...

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    It is the only ROM test that uses the PAMG-1 protein in amniotic fluid to give a 99% accurate result in minutes, at any gestational age. No speculum examination necessary. In a study of its usefulness in the management of PROM, AmniSure significantly increased clinician confidence and resulted in a change in the care and management of a third ...

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    ROM Plus® Rupture of Membranes Test. ROM Plus is a diagnostic test for premature rupture of membranes (PROM) in pregnant women. It is unique in that it detects both Alpha-fetoprotein (AFP) and Insulin-like growth factor-binding protein 1 (IGFBP-1) using a monoclonal/polyclonal antibody approach–improving its sensitivity. LEARN MORE.

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  • Meta-analysis of studies on biochemical marker tests

    2014-5-31 · A search of the PubMed database was conducted to identify all published studies, up to April 2013, relating to the rapid tests Actim® PROM and AmniSure®, without language restrictions and using a combination of the predefined search terms: PAMG-1 test, IGFBP-1 test, PAMG-1 PROM test, IGFBP-1 PROM test, placental alpha microglobulin-1 PROM ...

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    AmniSure is the quickest and easiest way to confirm a PROM diagnosis - and there's no need to wait for the registrar. AmniSure is a non-invasive bedside test that can be performed by a doctor, hospital nurse or midwife. It doesn't require a speculum examination, …

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    Research [1] shows that 47% of the time clinicians are not confident in their diagnosis of PROM based on history and examination alone. But the use of AmniSure, a quick, non-invasive bedside test, provides the information they need to make a confident diagnosis.

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    1999-8-1 · Insulin-like growth factor binding protein-1 (IGFBP-1; previously also called placental protein-12) is a 25-kD protein synthesized and secreted by the fetal and adult liver and maternal decidua.13, 14 In the maternal circulation, concentration of IGFBP-1 increases during pregnancy, and it is a major protein in the amniotic fluid (AF) from the ...

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